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Hyperpolarized proton MRI used to observe metabolic processes in real time


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IMAGE: The phantom used for hyperpolarized imaging, with an illustration of imaging slices acquired using the new technique.
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Credit: photo/©: Laurynas Dagys, University of Southampton
Magnetic resonance imaging (MRI) is already widely used in medicine for diagnostic purposes. Hyperpolarized MRI is a more recent development and its research and application potential has yet to be fully explored. Researchers at Johannes Gutenberg University Mainz (JGU) and the Helmholtz Institute Mainz (HIM) have now unveiled a new technique for observing metabolic processes in the body. Their singlet-contrast MRI method employs easily-produced parahydrogen to track biochemical processes in real time. The results of their work have been published in ....

Novosibirskaya Oblast , United Kingdom , Dmitry Budker , Gerd Buntkowsky , James Eills , Researchers At Johannes Gutenberg University Mainz , Budker Lab , University Of Southampton , Angewandte Chemie International Edition , Helmholtz Institute Mainz , Innovative Training Network , Johannes Gutenberg University Mainz , Professor Dmitry Budker , Parahydrogen Induced Polarization , Professor Gerd Buntkowsky , Physical Chemistry , Condensed Matter , Institute Mainz , Training Network , Ultra Low Field , American Physical , Biomechanics Biophysics , Molecular Biology , Chemistry Physics Materials Sciences , Atomic Molecular Particle Physics , Medicine Health ,

Researchers reveal 3D structure responsible for gene expression


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VIDEO: To reconstruct a 3D image of the human Mediator-bound transcription pre-initiation complex, researchers first captured hundreds of thousands of images of the Med-PIC complex. They then used computational methods to.
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Credit: Northwestern University
For the first time ever, a Northwestern University-led research team has peered inside a human cell to view a multi-subunit machine responsible for regulating gene expression.
Called the Mediator-bound pre-initiation complex (Med-PIC), the structure is a key player in determining which genes are activated and which are suppressed. Mediator helps position the rest of the complex RNA polymerase II and the general transcription factors at the beginning of genes that the cell wants to transcribe. ....

United States , Ryan Abdella , Anna Talyzina , H Foundation , Chicago Community , Northwestern Chemistry Of Life Sciences Institute , National Institutes Of Health , Northwestern Weinberg College Of Arts , American Cancer Society , Chicago Biomedical Consortium , Northwestern University Led , Weinberg College , Roger Kornberg , Life Sciences Institute , Searle Funds , Chicago Community Trust , National Institutes , Cell Biology , Nanotechnology Micromachines , ஒன்றுபட்டது மாநிலங்களில் , ஏச் அடித்தளம் , சிகாகோ சமூக , வடமேற்கு வேதியியல் ஆஃப் வாழ்க்கை அறிவியல் நிறுவனம் , தேசிய நிறுவனங்கள் ஆஃப் ஆரோக்கியம் , வடமேற்கு வெயின்பெர்க் கல்லூரி ஆஃப் கலைகள் , அமெரிக்கன் புற்றுநோய் சமூகம் ,

Study: Lowering the activity of KRAS gene can help fight pancreatic cancer


Study: Lowering the activity of KRAS gene can help fight pancreatic cancer
If clinicians could stop mutations of the KRAS gene in pancreatic cancer – which happens in more than 90 percent of pancreatic cancer cases and drastically reduces response to immunotherapy – the chances of improving treatment for this deadly form of cancer would be increased.
A collaborative study by Stony Brook University scientists, published in
Nature Communications, takes an initial step toward better understanding how KRAS drives immune evasion and demonstrates a lowering of the KRAS activity resulting in a more favorable immune environment to fight cancer.
Previous strategies to block the KRAS oncogene therapeutically have focused on counteracting its growth-promoting role in cancer. ....

Nancyc Reich , Oleksi Petrenko , Emily Henderson , Renaissance School Of Medicine , Nature Communications , Stony Brook University , Department Of Microbiology , Research Assistant Professor , Department Of Pathology , Stony Brook University Cancer Center , Renaissance School , Stony Brook , Scott Powers , Clinical Cancer Genomics , Stony Brook University Cancer , Pancreatic Cancer , எமிலி ஹென்டர்சன் , மறுமலர்ச்சி பள்ளி ஆஃப் மருந்து , இயற்கை தகவல்தொடர்புகள் , ஸ்டோனி சிற்றாறு பல்கலைக்கழகம் , துறை ஆஃப் நுண்ணுயிரியல் , ஆராய்ச்சி உதவியாளர் ப்ரொஃபெஸர் , துறை ஆஃப் நோயியல் , ஸ்டோனி சிற்றாறு பல்கலைக்கழகம் புற்றுநோய் மையம் , மறுமலர்ச்சி பள்ளி , ஸ்டோனி சிற்றாறு ,

Fossilized feeding frenzy

An international team of scientists with Fridgeir Grímsson from the University of Vienna has found a previously unknown fossil fly species in old lake sediments of the Messel Pit, a UNESCO World Heritage Site in Germany. In the stomach of the fossil insect, pollen from various plants could be detected, which allows rare insights into the feeding behavior, the ecology and the role of the fly as a pollinator. The study was published in Current Biology . ....

Department Of Botany , Biodiversity Research Of The University Vienna , Biodiversity Research , Current Biology , Plant Sciences , துறை ஆஃப் தாவரவியல் , பல்லுயிர் ஆராய்ச்சி ஆஃப் தி பல்கலைக்கழகம் வியன்னா , பல்லுயிர் ஆராய்ச்சி , தற்போதைய உயிரியல் , ஆலை அறிவியல் ,