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A Canadian success story: world-first to treat Fabry disease with gene therapy


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IMAGE: Darren Bidulka rests after his modified blood stem cells were transplanted into him at the Foothills Medical Centre in Calgary in 2017, allowing him to stop his enzyme therapy. (From.
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Credit: Courtesy of Darren Bidulka
(Thursday, Feb. 25, 2021, Toronto) Results of a world-first Canadian pilot study on patients treated with gene therapy for Fabry disease show that the treatment is working and safe.
The Canadian research team was the first to use gene therapy in 2017 to treat patients with Fabry disease, a rare, chronic illness that can damage major organs and shorten lives. They report their findings today in the journal ....

City Of , United Kingdom , Stephen Couban , Darren Bidulka , Aneal Khan , Michael West , Armand Keating , Christiane Auray Blais , Ryan Deveau , Anthony Rupar , Amicus Therapeutics , London Health Sciences Centre , University Health Network , Nature Communications , Michener Institute For Education , Alberta Health Services , Takeda Pharmaceuticals , University Of Toronto , Fund Professor , Kidney Foundation Of Canada , Avrobio Inc , Alberta Children Hospital Research Institute , Toronto Rehabilitation Institute , Cumming School Of Medicine , Alberta Health Service Foothills Medical Centre , Senior Scientist At Princess Margaret Cancer Centre ,

CAR T-cell therapy generates lasting remissions in patients with multiple myeloma


Credit: Dana-Farber Cancer Institute
In a major advance in the treatment of multiple myeloma, a CAR T-cell therapy has generated deep, sustained remissions in patients who had relapsed from several previous therapies, an international clinical trial has found.
In a study posted online today by the
New England Journal of Medicine, trial leaders report that almost 75% of the participants responded to the therapy, known as idecabtagene vicleucel (ide-cel), and one-third of them had a complete response, or disappearance of all signs of their cancer. These rates, and the duration of the responses, are significantly better than those produced by currently available therapies for patients with multiple relapses, according to investigators. ....

New York , United States , Nordrhein Westfalen , Region Flamande , Comunidad Autonoma De Cataluna , San Francisco , Dana Farber Cancer Institute , Baden Wuberg , United Kingdom , Institut Catala , Liping Huang , Triasi Pujol , Alessandro Rambaldi , Donna Reece , Nikhil Munshi , Jamien Connarn , Monica Massaro , David Siegel , Shari Kaiser , Nina Shah , Deepu Madduri , Michele Cavo , Hermann Einsele , Territoriale Papa Giovanni , Philippe Moreau , Yi Lin ,

Measuring hemoglobin levels with AI microscope, microfluidic chips


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IMAGE: A diagnostic solution to enable simple and cost-effective hemoglobin estimation using a microfluidic chip and AI-powered automated microscope.
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Credit: SigTuple Technologies Pvt. Ltd.
WASHINGTON, February 23, 2021 One of the most performed medical diagnostic tests to ascertain the health of patients is a complete blood count, which typically includes an estimate of the hemoglobin concentration. The hemoglobin level in the blood is an important biochemical parameter that can indicate a host of medical conditions including anemia, polycythemia, and pulmonary fibrosis.
In
AIP Advances, by AIP Publishing, researchers from SigTuple Technologies and the Indian Institute of Science describe a new AI-powered imaging-based tool to estimate hemoglobin levels. The setup was developed in conjunction with a microfluidic chip and an AI-powered automated microscope that was designed for deriving the total as well as differential coun ....

United States , Siva Gorthi , Srinivasan Kandaswamy , Tathagato Rai Dastidar , Lokanathan Arcot Srinivasan Kandaswamy , Indian Institute Of Science , Sigtuple Technologies , Indian Institute , Lokanathan Arcot , Anil Modali , Sai Siva Gorthi , Tathagato Rai , Biomechanics Biophysics , Chemistry Physics Materials Sciences , Medicine Health , Technology Engineering Computer Science , ஒன்றுபட்டது மாநிலங்களில் , சிவா கோர்த்தி , ஸ்ரீநிவாசன் கந்தசுவாமி , லோகநாதன் ஆர்கோட் ஸ்ரீநிவாசன் கந்தசுவாமி , இந்தியன் நிறுவனம் ஆஃப் அறிவியல் , இந்தியன் நிறுவனம் , லோகநாதன் ஆர்கோட் , சாய் சிவா கோர்த்தி , பயோமெக்கானிக்ஸ் உயிர் இயற்பியல் , வேதியியல் இயற்பியல் பொருட்கள் அறிவியல் ,

Study reveals extremely low detection of SARS-CoV-2 on surfaces in oncology facilities


Study reveals extremely low detection of SARS-CoV-2 on surfaces in oncology facilities
Researchers from Rutgers Cancer Institute of New Jersey, the state s only National Cancer Institute-designated Comprehensive Cancer Center, evaluated the frequency of SARS-CoV-2, the virus that causes COVID-19, on various environmental surfaces in outpatient and inpatient hematology/oncology settings located within Rutgers Cancer Institute and Robert Wood Johnson University Hospital, an RWJBarnabas Health facility.
The study revealed extremely low detection of SARS-CoV-2 on environmental surfaces across multiple outpatient and inpatient oncology areas, including an active COVID-19 floor. Andrew M. Evens, DO, MSc, FACP, associate director for clinical services and director of the Lymphoma Program at Rutgers Cancer Institute and medical director of the oncology service line at RWJBarnabas Health, is senior author of the work, which has been published in the February 18 online edition of ....

Andrewm Evens , Emily Henderson , Lymphoma Program At Rutgers Cancer Institute , Rutgers Robert Wood Johnson Medical School , Robert Wood Johnson University Hospital , Rutgers Cancer Institute Of New Jersey , National Cancer Comprehensive Center , Rutgers Cancer Institute , Rwjbarnabas Health , New Jersey , Lymphoma Program , Rutgers Robert Wood Johnson Medical , Sars Cov 2 , T Cell , எமிலி ஹென்டர்சன் , லிம்போமா ப்ரோக்ர்யாம் இல் ரட்ஜர்ஸ் புற்றுநோய் நிறுவனம் , ரட்ஜர்ஸ் ராபர்ட் மரம் ஜான்சன் மருத்துவ பள்ளி , ராபர்ட் மரம் ஜான்சன் பல்கலைக்கழகம் மருத்துவமனை , ரட்ஜர்ஸ் புற்றுநோய் நிறுவனம் ஆஃப் புதியது ஜெர்சி , தேசிய புற்றுநோய் விரிவான மையம் , ரட்ஜர்ஸ் புற்றுநோய் நிறுவனம் , புதியது ஜெர்சி , லிம்போமா ப்ரோக்ர்யாம் , ரட்ஜர்ஸ் ராபர்ட் மரம் ஜான்சன் மருத்துவ , டி செல் ,