May 12, 2021 | While league officials may have wanted to keep the NFL schedule a secret until Wednesday night's official 8 p.m. ET release, plenty of leaks made that impossible. So oddsmakers got on board early and had all the NFL Week 1 odds up well before nightfall Wednesday. And not surprisingly, the first game out of the gate is a popular one on the NFL Week 1 odds board. On Thursday, Sept. 9, the defending Super Bowl champion Tampa Bay Buccaneers play host to the Dallas Cowboys. Among other marquee Week 1 games: the Cleveland Browns visit the Kansas City Chiefs; the Green Bay Packers travel to face the New Orleans Saints; and the Monday nighter has the Las Vegas Raiders hosting the Baltimore Ravens.