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 E-Mail IMAGE: Using EMBL Hamburg's world-class beamline P12 at DESY's PETRA III synchrotron, researchers directed powerful X-ray beams at artificial proteins called coiled-coil origami proteins. view more  Credit: Credit: Fabio Lapenta / National Institute of Chemistry, Ljubljana, Slovenia Origami may sound more like art than science, but a complex folding pathway that proteins use to determine their shape has been harnessed by molecular biologists, enabling them to build some of the most complex synthetic protein nanostructures to date. Using EMBL Hamburg's world-class beamline P12 ...

 E-Mail Researchers have genetically engineered a probiotic yeast to produce beta-carotene in the guts of laboratory mice. The advance demonstrates the utility of work the researchers have done to detail how a suite of genetic engineering tools can be used to modify the yeast. "There are clear advantages to being able to engineer probiotics so that they produce the desired molecules right where they are needed," says Nathan Crook, corresponding author of the study and an assistant professor of chemical and biomolecular engineering at North Carolina State University. "You're not just deliveri...

''This is the first demonstration that virulence of human pathogenic bacteria can be mitigated by molecules secreted in probiotic milk products, such as yogurt or kefir,'' said BGU Prof. Jelinek. ''Our research illuminates the mechanism by which milk fermented probiotics can protect against pathogenic infections and aid the immune system. We look forward to administering these drug candidates to patients who are experiencing a cytokine storm due to COVID-19 infection, or people suffering from acute inflammatory bowel pathologies, such as Crohn's disease.''

 E-Mail BOSTON - (April 12, 2021) - A new source of energy expending brown fat cells has been uncovered by researchers at the Joslin Diabetes Center, which they say points towards potential new therapeutic options for obesity. According to the new report, published today by Nature Metabolism, the key lies in the expression of a receptor called Trpv1 (temperature-sensitive ion channel transient receptor potential cation subfamily V member 1) -- a protein known to sense noxious stimuli, including pain and temperature. Specifically, the authors point to smooth muscle cells expressing the Trpv1...

Date Time Technique allows mapping of epigenetic information in single cells at scale Decoding epigenomic information from individual cells from the mouse brain. Histones are attached to DNA as beads on a string, with different versions decorating the genome as “epigenetic stickers”, labelling which genes are turned on or off. The method single-cell CUT&Tag allows to examine tens of thousands of single cells at the same time to determine their histone profiles. Illustration by Amagoia Agirre. Histones are tiny proteins that bind to DNA and hold information that can help turn on or off ind...