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Sanofi to explore acquisition of cancer drugmaker Mirati- Bloomberg News

Sanofi to explore acquisition of cancer drugmaker Mirati- Bloomberg News
biztoc.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from biztoc.com Daily Mail and Mail on Sunday newspapers.

France , Marcy-letoile , Rhôalpes , Paris , France-general- , French , Sanofi-pasteur , Reuters , Mirati-therapeutics , Bloomberg-news ,

Serotype distribution and antimicrobial susceptibility of invasive Streptococcus pneumoniae isolates among adult and elderly population before and after introduction of pneumococcal conjugate vaccine in Casablanca, Morocco | BMC Infectious Diseases

Streptococcus pneumoniae (S. pneumoniae), remains a major cause of mortality and morbidity worldwide. The objective of this study was to determine the trends of invasive pneumococcal diseases (IPD) in adult and elderly population in Casablanca (Morocco) before and after introduction of pneumococcal conjugate vaccine (PCV) by determining the distribution of pneumococcal serotypes and antibiotic resistance profile of isolated strains. The proposed study is a retrospective laboratory-based surveillance of IPD in hospitalized adult (15–59 years old) and elderly (≥ 60 years old) patients in Ibn Rochd University Hospital Centre from 2007 to 2019 (13 years). All the 250 non-duplicate clinical invasive isolates from adult and elderly patients, confirmed as S. pneumoniae according to the laboratory standard identification procedures, are included in this study. A significant decrease of the overall incidence in IPD was observed only in adults from 0.71 to 0.54/100000 populations (P  =  0.02) and to 0.47/100000 populations (P  =  0.0137) in the early and mature post-vaccine period respectively compared to the pre-vaccine period. Our results also showed a significant reduction in the overall prevalence of vaccine serotypes from 28.17 to 6.90% (P  =  0.0021) for the PCV-10 serotypes, and from 46.48 to 25.86% (P  =  0.0164) for the PCV-13 serotypes only in the mature post-vaccine period (2015–2019). In parallel, the rate of non-vaccine serotypes did not significantly change in the early post-vaccine period (2011–2014) while it increased considerably from 54 to 74.14% (P  =  0.0189) during the mature post-vaccine period. The rate of penicillin non-susceptible pneumococcal isolates decreased significantly from 23.94 to 8.77% (P  =  0.02) in adult patients, and the rate of cotrimoxazole non-susceptible pneumococcal isolates significantly decreased from 29.58 to 8.77% in the early post-vaccine period (P  =  0.003) and to 7.24% in the mature post-vaccine period (P  =  0.0007). Although childhood vaccination has considerably reduced the incidence of IPD in adult population through the herd effect, IPD remain a real public health problem due to the alarming increase in non-vaccine serotypes (NVS) and the lack of herd effect among elderly population. The rate of antibiotic resistance was relatively low. Nevertheless, resistance constitutes a serious problem to the therapeutic arsenal due to the known capacity for genetic dissemination in the pneumococcus.

Casablanca , Grand-casablanca , Morocco , Nouaceur , Region-de-chaouia-ouardigha , Basingstoke , Hampshire , United-kingdom , Mediouna , Tanger-téuan , Denmark , Copenhagen

bioMérieux and Jackson Family Wines Introduce Groundbreaking Innovation for Wine Quality – BOTTLESAFE™

bioMérieux and Jackson Family Wines Introduce Groundbreaking Innovation for Wine Quality – BOTTLESAFE™
wineindustryadvisor.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from wineindustryadvisor.com Daily Mail and Mail on Sunday newspapers.

Australia , Philadelphia , Pennsylvania , United-states , Marcy-letoile , Rhôalpes , France , Sonoma-county , California , Italy , South-africa , Chile

bioMérieux Launches First-of-Its-Kind Assay to Predict Juice Contamination

MARCY-L’ETOILE, France– bioMérieux, a world leader in the field of in vitro diagnostics announced today the launch of GENE-UP® PRO ACB, a new assay for juice quality and safety programs. GENE-UP® PRO ACB upgrades the existing traditional Alicyclobacillus (ACB) approaches, in that it can predict guaiacol production to prevent spoilage and stop false alarms. Early screening of Alicyclobacillus spp. in fruit juices is a major goal for the food industry. ACB contamination can produce guaiacol, the enzyme that alters juice taste and odor. A 2017 survey of juice manufacturers revealed that over 90% of participants indicated that better control over

France , Marcy-letoile , Rhôalpes , Ben-pascal , Abigail-snyder , Predictive-diagnostic-innovation-center , Sentinel-team , Cornell-university , Assistant-professor , Microbial-food-safety , Invisible-sentinel-team , Chief-business-officer

Blood culture surveillance in a secondary care hospital in Benin: epidemiology of bloodstream infection pathogens and antimicrobial resistance | BMC Infectious Diseases

Although global surveillance of antimicrobial resistance (AMR) is considered key in the containment of AMR, data from low- and middle-income countries, especially from sub-Saharan Africa, are scarce. This study describes epidemiology of bloodstream infections and antimicrobial resistance rates in a secondary care hospital in Benin. Blood cultures were sampled, according to predefined indications, in BacT/ALERT FA Plus and PF Plus (bioMérieux, Marcy-l’Etoile, France) blood culture bottles (BCB) in a district hospital (Boko hospital) and to a lesser extent in the University hospital of Parakou. These BCB were incubated for 7 days in a standard incubator and twice daily inspected for visual signs of growth. Isolates retrieved from the BCB were processed locally and later shipped to Belgium for reference identification [matrix-assisted laser desorption/ionization time-of-flight spectrometry (MALDI-TOF)] and antibiotic susceptibility testing (disk diffusion and E-tests). From October 2017 to February 2020, 3353 BCB were sampled, corresponding to 3140 blood cultures (212 cultures consisting of  > 1 BCB) and 3082 suspected bloodstream infection (BSI) episodes. Most of these cultures (n = 2471; 78.7%) were sampled in children < 15 years of age. Pathogens were recovered from 383 (12.4%) cultures, corresponding to 381 confirmed BSI. 340 of these pathogens were available and confirmed by reference identification. The most common pathogens were Klebsiella pneumoniae (n = 53; 15.6%), Salmonella Typhi (n = 52; 15.3%) and Staphylococcus aureus (n = 46; 13.5%). AMR rates were high among Enterobacterales, with resistance to third-generation cephalosporins in 77.6% of K. pneumoniae isolates (n = 58), 12.8% of Escherichia coli isolates (n = 49) and 70.5% of Enterobacter cloacae isolates (n = 44). Carbapenemase production was detected in 2 Escherichia coli and 2 Enterobacter cloacae isolates, all of which were of the New Delhi metallo-beta lactamase type. Methicillin resistance was present in 22.4% of S. aureus isolates (n = 49). Blood cultures were successfully implemented in a district hospital in Benin, especially among the pediatric patient population. Unexpectedly high rates of AMR among Gram-negative bacteria against commonly used antibiotics were found, demonstrating the clinical and scientific importance of clinical bacteriology laboratories at this level of care.

United-states , Gembloux , Waals-gewest , Belgium , Washington , Marcy-letoile , Rhôalpes , France , Austria , Leuven , Region-flamande , Canada

French multidisciplinary consortium ARPEGE awarded public funding of close to €9 million to fight antibiotic resistance

/PRNewswire/ -- The ARPEGE[1] project aims to develop a set of solutions to strengthen the ability of healthcare institutions to fight antibiotic resistance....

France , Germany , United-states , United-kingdom , New-delhi , Delhi , India , Marcy-letoile , Rhôalpes , French , Marc-lemonnier , Jean-tirole

French multidisciplinary consortium ARPEGE awarded public funding of close to €9 million to fight antibiotic resistance

/PRNewswire/ -- The ARPEGE[1] project aims to develop a set of solutions to strengthen the ability of healthcare institutions to fight antibiotic resistance....

France , Germany , United-states , United-kingdom , New-delhi , Delhi , India , Marcy-letoile , Rhôalpes , French , Peutique-economique , Jim-oneill

Antabio; bioMérieux; Hospices Civils de Lyon; Toulouse School of Economics: French multidisciplinary consortium ARPEGE awarded public funding of close to €9 million to fight antibiotic resistance

· ARPEGE is designed to achieve solutions to antibiotic resistance by combining preventive, diagnostic, therapeutic and economic approaches for the first time. · Led by the French biotech

France , Germany , United-states , United-kingdom , New-delhi , Delhi , India , Marcy-letoile , Rhôalpes , French , Peutique-economique , Jim-oneill