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COVID-19 vaccination delays could bring more virus variants, impede efforts to end pandemic

Scientists say high rates of viral spread in a partially immunized population could encourage mutations that make virus harder to contain.

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New covid-19 strains: What scientists know about coronavirus variants

New covid-19 strains: What scientists know about coronavirus variants
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Vials of Covishield, AstraZeneca-Oxford's Covid-19 coronavirus vaccine are pictured inside a lab where they are being manufactured at India's Serum Institute in Pune on January 22, 2021. (Photo by Punit PARANJPE / AFP)
(AFP)
. Updated: 23 Jan 2021, 02:01 PM IST The Wall Street Journal
New versions of the novel coronavirus are spreading across the globe. Researchers fear the new lineages may spread more easily—and one may be more deadly.
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Scientists around the world are scrambling to learn more about previously unknown variants of the coronavirus that seem to spread from person to person more readily than other versions of the Covid-19-causing pathogen—including one variant that may also be more deadly.

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The Coronavirus Is Evolving the Same Mutations Around the World

A Troubling New Pattern Among the Coronavirus Variants
Sarah Zhang
© Simoul Alva
For most of 2020, the coronavirus that causes COVID-19 jumped from human to human, accumulating mutations at a steady rate of two per month—not especially impressive for a virus. These mutations have largely had little effect.
But recently, three distinct versions of the virus seem to have independently converged on some of the same mutations, despite being thousands of miles apart in the United Kingdom, South Africa, and Brazil. (A mutation is a genetic change; a variant is a virus with a specific set of mutations.) The fact that these mutations have popped up not one, not two, but now three times—that we know of—in variants with unusual behavior suggests that they confer an evolutionary advantage to the virus. All three variants seem to be becoming more common. And all three are potentially more transmissible.

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Why the New Covid-19 Variants Could Be More Infectious

Why the New Covid-19 Variants Could Be More Infectious
8 countries in the @WHO_Europe region have now identified the new COVID-19 variant VOC-202012/01
(AP)Premium
. Updated: 17 Jan 2021, 12:37 PM IST The Wall Street Journal
Mutations in the virus’s appendage have created potentially more infectious versions of the pathogen, including one currently circulating around the world
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As viruses replicate, they change, or mutate. Some mutations give these viral variants an edge, such as being better able to latch on to and infect human cells. That’s what scientists think happened with the coronavirus variant that swept through the U.K. recently and which is now showing up in states across the U.S.

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Listen: Coronavirus Mutations

How bad are the new COVID-19 variants, really?

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Pfizer-BioNTech vaccine protects against key mutation found in fast-spreading virus variants, study shows

Pfizer-BioNTech vaccine protects against key mutation found in fast-spreading virus variants, study shows
Carolyn Y. Johnson, The Washington Post
Jan. 8, 2021
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Ossineke Pharmacy supervisor, Sarah Tarkington, left, and MidMichigan Medical Center Pharmacy Manager, Laura Caplis, prepare the first Pfizer-BioNTech vaccines to be administered in December in Alpena, Mich.photo for The Washington Post by Elaine Cromie.
The Pfizer-BioNTech vaccine works against a key mutation found in new, fast-spreading coronavirus variants first discovered in the United Kingdom and South Africa, and now spreading across the globe.
The finding,published late Thursday night, but not yet peer-reviewed, bolsters many scientists' expectations that the immune response triggered by vaccines will be broad enough to counter the new, highly contagious variants.

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The new coronavirus is mutating—what does that mean for vaccines?

Will vaccines stop the new coronavirus strains? Here's what scientists say.
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Even as scientists around the world are closely monitoring the spread of a new, more infectious variant of the novel coronavirus, they have spotted a brand-new, potentially more worrisome mutation—one that could have a far greater impact on the abilities of vaccines to protect people from infection.
About the mutations
In December 2020, U.K. Prime Minister Boris Johnson and England's CMO Chris Whitty said scientists identified a new strain of the new coronavirus—labeled B 1.1.7, which contains multiple mutations from SARS-CoV-2—through
Public Health England's genomic surveillance.

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Could New COVID Variants Undermine Vaccines? Labs Scramble to Find Out

Scientific American
Could New COVID Variants Undermine Vaccines? Labs Scramble to Find Out
Researchers race to determine why variants identified in Britain and South Africa spread so quickly and whether they’ll compromise vaccines
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Paramedics assess a Covid-19 patient in Lenasia, Johannesburg, on January 4, 2021. Currently suffering a second wave of infections, of which the majority are a new variant of the coronavirus, South Africa is the hardest hit country on the African continent. Credit: Michele Spatari
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As concern grows over faster-spreading variants of coronavirus, labs worldwide are racing to unpick the biology of these viruses. Scientists want to understand why SARS-CoV-2 variants identified in the United Kingdom and South Africa seem to be spreading so quickly, and whether they might diminish the potency of vaccines or overcome natural immunity and lead to spate of reinfections.

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LankaWeb – Vaccines and our own antibodies hold fast against mutant Covid army

Posted on December 27th, 2020
Courtesy The Times (UK)
Science offers hope despite fears about the effect of quick-spreading coronavirus variants
Borders closed, lockdowns were tightened and dire warnings of aggressive new outbreaks were issued. Scientists worried about the vulnerability of children and politicians agonised over shutting schools.
There was scant relief on the coronavirus front last week, as the discovery of an alarming pair of mutant strains played havoc with the Christmas plans — not to mention the fraying nerves — of Britons, South Africans and a rapidly growing number of other nationalities.
Yet a singular effort by a weary microbiologist in Texas offered at least a glimpse of hope that the mutant army of variant coronavirus strains will ultimately be defeated by science.

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Explained: Beware the UK mutant

in Antarctica, the pandemic has reached every continent. And a
mutant virus has emerged in the United Kingdom, which threatens to shut down the world yet again — a world just beginning to recover from lockdowns and movement restrictions.
The mutation of viruses
The genetic material or genome of SARS-CoV-2 is a ribonucleic acid (RNA) made up of over 30,000 units (called nucleotides). Among the families of RNA viruses, the coronaviruses have the largest genome. Most other RNA viruses have on average about 10,000 nucleotides. When genomes replicate — any genomes, whether DNA or RNA, from the smallest viruses to humans — there are random errors (or mutations). While higher organisms have the machinery to correct these errors, viruses and especially the RNA ones, don’t.

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