it's the first and only approved chemo-free combination of two immunotherapies that works together in different ways to harness the power of the immune system. opdivo plus yervoy equals a chance for more days. more nights. more beautiful weekends. more ugly sweaters. more big hugs. more small outings. opdivo and yervoy can cause your immune system to attack normal organs and tissues in your body and affect how they work. this may happen during or after treatment has ended and can become serious and lead to death. some of these problems may happen more often when opdivo is used with yervoy. see your doctor right away if you have a new or worse cough; chest pain; shortness of breath; diarrhea; severe stomach pain; nausea or vomiting; dizziness; fainting; extreme tiredness; weight changes; constipation; excessive thirst; changes in urine or eyesight; rash; itching; confusion; memory problems; muscle pain or weakness; joint pain; flushing; fever; or tingling in hands and feet. these are not all the possible side effects. tell your doctor about all your medical conditions including immune system problems, or if you've had an organ transplant