serious allergic reactions, like low blood pressure; trouble breathing; throat tightness; face, lip or tongue swelling, rash, itching or hives have happened. tell your doctor about dental problems, as severe jaw bone problems may happen or new or unusual pain in your hip, groin, or thigh, as unusual thigh bone fractures have occurred. speak to your doctor before stopping prolia®, as spine and other bone fractures have occurred. prolia® can cause serious side effects, like low blood calcium; serious infections, which could need hospitalization; skin problems; and severe bone, joint, or muscle pain. if your bones aren't getting stronger isn't it time for a new direction? why wait? ask your doctor about prolia.