where can a healthier heart lead you? for people with heart failure taking entresto, it may lead to a world of possibilities. entresto is a heart failure medicine prescribed by most cardiologists. it was proven superior at helping people stay alive and out of the hospital. heart failure can change the structure of your heart so it may not work as well. entresto helps improve your heart's ability to pump blood to the body. and with a healthier heart, there's no telling where life may take you. don't take entresto if pregnant; it can cause harm or death to an unborn baby. don't take entresto with an ace inhibitor or aliskiren, or if you've had angioedema with an ace or arb. the most serious side effects are angioedema,