In 2015, Iran agreed to a long-term deal on its nuclear program with a group of world powers known as the P5+1 — the U.S., U.K., France, China, Russia, and Germany. Under the Joint Comprehensive Plan of Action (JCPOA), or Iran nuclear deal, Iran agreed to limit its sensitive nuclear activities and to allow international inspectors in return for the lifting of crippling economic sanctions. However, in 2018, President Donald Trump removed the U.S. from this deal, and tensions between the U.S. and Iran ramped up during his administration. With President Joe Biden now in office, there are new questions about the U.S.–Iran relationship moving forward. Reports have indicated that the Biden administration will take steps to reenter the deal under the condition that Iran complies more closely with its regulations. Is Iran likely to reenter the deal? What will U.S. policy toward Iran look like under a Biden administration? And how do the broader relationships between Iran and the rest of the Middle East affect the U.S.?