outbreak as a pandemic. john lewis confirms another raft of store closures as it announces an annual pre—tax loss of £517 million thought to be the first annual loss in its history. and, coming up this hour, we'll be speaking to the absolutely fabulous joanna lumley. she's backing a nepalese restaurant owner who's been delivering meals throughout the pandemic and is due to deliver his 100,000 today. a serving police officer is being questioned on suspicion of the kidnap and murder of sarah everard, who was last seen in south london more than a week ago. police investigating her disappearance have found what they believe to be human remains in woodland in kent. the metropolitan police commissioner, dame cressida dick, said it was incredibly rare for someone to be abducted on the street and she understood that women may be feeling scared. aru na iyengar reports. all along the route sarah took from clapham common over a week ago, posters bearing her image are on every lamp post and bus stop, appealing for information. yesterday evening, police investigating her disappearance discovered what appears to be human remains in woodland in ashford, kent. police say they are not yet able to confirm any identity, and that may take considerable time. 0fficers also searched his house in deal, kent. cars were taken away. it is believed to be the home of a serving police officer. he has been arrested on suspicion of sarah's kidnap and murder, and over a separate allegation of indecent exposure. the officer, in his 40s, was responsible for guarding diplomatic buildings. he was not on duty on the night sarah disappeared. a woman in her 30s was also arrested on suspicion of assisting an offender. the news today that it was a metropolitan police officer who was arrested on suspicion of sarah's murder, has sent shock waves and anger through the public and through the met. i speak on behalf of all my colleagues when i say that we are utterly appalled. sarah's disappearance in these awful and wicked circumstances, i know, are every family's worst nightmare. the met commissioner said it was incredibly rare for a woman to be abducted from our streets. patrols have been stepped up in this area of south london. sarah, a marketing executive, had been at a friend's house on leathwaite road, close to clapham common. she left there at around nine in the evening to return to her home in brixton, about 50 minutes walk away. police believe she made her way across clapham common. this footage showed sarah on poynder road at around 9:30pm. it was the last time she was seen. sarah's family is being supported by specialist police officers. her family and friends want people to come forward to help police with anything they saw that night. aruna iyengar, bbc news. 0ur reporter, simonjones, is in ashford in kent. close to the scene of one of the air as police are searching is part of the investigation in this case are what is the latest officers are saying? what is the latest officers are sa in: ? ., . ., what is the latest officers are sa in? .,. . ,. , ., saying? police have described what ha--ened saying? police have described what happened to _ saying? police have described what happened to sarah _ saying? police have described what happened to sarah everard - saying? police have described what happened to sarah everard as - saying? police have described what| happened to sarah everard as every family's worst nightmare and they're determined to find answers for her family. this morning at the scene where human remains were found yesterday there has been a lot of police activity, we've seen vehicles coming and going, we have seen sniffer dogs being exercised so there are hundreds of officers involved in this case and those investigations are very much continuing. initially the focus had been on south london and clapham where she was last seen just over a week ago but yesterday it dramatically shifted to kent, as well as the search here where the remains were found. also a property believed to belong to the suspect was being searched in deal and speaking to neighbours there, they are saying their sense is one shared by the metropolitan police were having to investigate one of their own. the shock waves they say being felt right across the force and in the wider community, too. silent, thank ou the wider community, too. silent, thank you very _ the wider community, too. silent, thank you very much. _ this case has started a national conversation about women's safety, and joining me now to talk about that is andrea simon, director of the end violence against women coalition. thank you very much for your time today. we saw dame cressida dick say yesterday in her statement that incidents like this, like the sarah everard case, where someone is apparently snatched off the street, are incredibly rare but what isn't rare is the fear of something that happening and you only have to look at the conversation on social media, women relating their experiences of feeling nervous on the streets to realise that it is an incredibly common experience, isn't it? it is a very common _ common experience, isn't it? it is a very common experience. - common experience, isn't it? it is a very common experience. that's . very common experience. that's right. there are lots of women who are worried about their safety and being a woman in a public space increases how vulnerable you are to violence and is worse at certain times of night and day and parts of the city. in london you see sexual assaults taking place in public spaces including on the transport network. it is a widespread, common experience and it means women are constantly making decisions about where they go and changing their roots, avoiding certain places, doing things like carrying keys in their hand, picking particular seats to sit on public transport, we are really aware of our surroundings and tuned in the risk. it is called the invisible safety network of women and the adaptations we make without thinking about it to minimise the potential of being a victim of crime. �* ., , ., crime. and many of those conversations _ crime. and many of those conversations on - crime. and many of those conversations on twitter, | crime. and many of those - conversations on twitter, women talking about what they do, steps they take actions they take to protect themselves. as well as that, men asking what they can do to help women feel safer on the streets because let's face it the sort of incident where someone is apparently snatched off the street... it usually happens to women, doesn't it? it usually happens to women, doesn't it? ., , ~ ., , a usually happens to women, doesn't it? ., , a it? it does. men are very much part ofthe it? it does. men are very much part of the solution _ it? it does. men are very much part of the solution and _ it? it does. men are very much part of the solution and can _ it? it does. men are very much part of the solution and can be - it? it does. men are very much part of the solution and can be a - it? it does. men are very much part of the solution and can be a real - of the solution and can be a real ally in these conversations, and men have a role to play in calling out problematic behaviour when they see it, in challenging their friends and families if they express views or behaviours they know to be wrong or make women feel uncomfortable. men can do a lot, they are part of the solution. �* , , , ., can do a lot, they are part of the solution. �*, , , ., ., , solution. let's be plain about this, a man is walking _ solution. let's be plain about this, a man is walking on _ solution. let's be plain about this, a man is walking on a _ solution. let's be plain about this, a man is walking on a quiet - solution. let's be plain about this, | a man is walking on a quiet street, a man is walking on a quiet street, a woman is in front of him, what can a woman is in front of him, what can a man do in that situation? if he takes as a basic assumption that woman might feel nervous, what should he do? i woman might feel nervous, what should he do?— woman might feel nervous, what should he do? i think we need to, all of us, should he do? i think we need to, all of us. we _ should he do? i think we need to, all of us, we need _ should he do? i think we need to, all of us, we need to _ should he do? i think we need to, all of us, we need to create - should he do? i think we need to, all of us, we need to create a - all of us, we need to create a situation where we can all occupy public spaces on the same terms. but i think it is where men are aware of how vulnerable women can be and thinking about their behaviour in relation to men. at its core, it is really about challenging some of the attitudes that often make these behaviours normalised at a very early stage, so doing a lot of preventative work in education, talking about healthy, respectful relationships and how women and men relate to each other is very important. relate to each other is very important-— relate to each other is very im ortant. .,, ., ., ., important. there was a lot of discussion — important. there was a lot of discussion about _ important. there was a lot of discussion about men - important. there was a lot of. discussion about men crossing important. there was a lot of- discussion about men crossing to the other side of the street or being on the phone, making some noise to make it clear their presence is... they are just walking down the street, there is nothing untoward about the fact they happen to be walking behind a woman. i've been looking at your latest report which i believe was published just last month or in january on the state of violence against women and girls. you've been saying this narrative about what should women do takes the focus away from the perpetrators but there is work that women and men can do. yes. that is a crucial— work that women and men can do. yes. that is a crucial point. _ work that women and men can do. jazz that is a crucial point. this can't be all about women taking steps to keep themselves safe. if it is going to end and get better, it's got to be about what we can do to prevent these things happening in the first place, what actions we can do to stop perpetrators. identify where situations can occur, where women feel more vulnerable and do something about that but there are lots of steps we can all take and we are all part of the solution to this. the leadership on this issue in making sure women's safety and violence against women and girls always remains a top priority for leaders and those in positions in power is really important, and that is at all levels so your local authorities can conduct women's safety audits and things like that, put things in place to make sure women feel safer when they are going around their lives, travelling to work and to school, and also we can do much more, as i was saying earlier, about educating men and women and girls and boys about how to respect each other and how to get along and challenge some of these really damaging attitudes around how to treat women at a very early stage. to treat women at a very early sta . e. �* . to treat women at a very early staue. �* ., ,, ., stage. andrea simon, campaigner auainst stage. andrea simon, campaigner against violence _ stage. andrea simon, campaigner against violence for _ stage. andrea simon, campaigner against violence for women, - stage. andrea simon, campaigner| against violence for women, thank you forjoining us today and for your thoughts on this. it's exactly one year since the world health organization officially declared the coronavirus outbreak as a pandemic — that's the point the disease was confirmed as a truly global problem. covid—i9 has so far claimed 2.6 million lives but there is hope on the horizon as vaccines reach some of the furthest corners of the world. our global health correspondent, naomi grimley, has been looking at the pandemic, one year in. it's been a year that most of us will remember for the rest of our lives. one of grief and loneliness on a scale none of us could have imagined. it is exactly 12 months since the world health organization officially sounded the alarm about the seriousness of covid—i9. we have therefore met the assessment that covid—i9 can be characterised as a pandemic. and, yet, after a whirlwind of scientific discoveries, we are now seeing vaccines being distributed to some of the most remote communities on earth. in brazil they've mounted a vaccination campaign reaching reservations and villages like this one deep in the amazon jungle. translation: i'm happy. we are grateful for the vaccination so we will not catch the disease and my people will get better. because of a new variant spreading their brazil has seen some of the worst death toll figures since the pandemic began in the last few days. but overall scientists are positive about bringing the pandemic to an end. we are in a much more powerful situation because we understand so much more about the virus now so i am very optimistic of the future, we have a better handle on the virus and we are able to keep up, i suppose, with the race against an evolving virus. this graph shows some of the differences in pay is, however, of vaccination rates globally. chile, israel and the us have powered ahead. faring less well are brazil, russia and china. in europe, there's been a huge amount of disquiet over disappointing vaccine rates. the situation in france has not been helped by negative remarks from president macron about the oxford/astrazeneca vaccine which he later retracted. this family doctor is doing his best to persuade reluctant patients. translation: there's always a hesitation and we have - to convince some patients. that's time and energy used. if we don't have support both from government and media, it's hard to go up from there. patients trust us but only to a certain extent. meanwhile, the international covax programme says it's delivered over 20 million doses to more than 20 developing countries, mostly in africa. but it is really only enough to vaccinate key medical workers. whether it is drive—through vaccinations in la all doctors vaccinations in la or doctors and nurses in nigeria, get ready for an increasingly divided world, depending on who has been vaccinated and who hasn't. with over 2.6 million deaths in the pandemic so far, everyone can agree that much better protections are needed to ensure it never happens again. naomi grimley, bbc news. let's get more on this and speak to professor anthony gordon, consultant in intensive care medicine and chair in anaesthesia and critical care at imperial college. he was also the uk's chief investigator into the trial of the rheumatoid arthritis drugs tocilizumab and sarilumab for covid treatment. good to have you with us today and one year on, where do you begin to take stock of the year we have had? it has been quite an amazing year. a very tiring yearfor it has been quite an amazing year. a very tiring year for everybody in the health service. but i think we have learnt a lot and we are in a much better place now than we were this time last year. a, much better place now than we were this time last year.— this time last year. a good place to start is to look _ this time last year. a good place to start is to look at _ this time last year. a good place to start is to look at treatment - this time last year. a good place to start is to look at treatment for - start is to look at treatment for covid and how it has changed over the year. pa, covid and how it has changed over the ear. �* , ., ., ., , , covid and how it has changed over the ear. �* , ., ., ., , the year. a year ago, this is a new virus, the year. a year ago, this is a new virus. none _ the year. a year ago, this is a new virus. none of _ the year. a year ago, this is a new virus, none of us _ the year. a year ago, this is a new virus, none of us had _ the year. a year ago, this is a new virus, none of us had seen - the year. a year ago, this is a new virus, none of us had seen it - virus, none of us had seen it before, none of us had any immunity to it and we were unsure what it was going to be like to treat. i think it took us by surprise. it wasn't just a virus that affected the lung. we learned fairly early on it was affecting many organs in the body which is what makes it such a deadly virus, when it is severe. in the treatments we've had really focused on that. we've learnt we need to tackle the body's response to the virus, which is when we have seen success so far over this last year. so, what led you to specifically investigate whether drug is already investigate whether drug is already in use for rheumatoid arthritis might work for a treatment for covid? ., ., , ., , covid? now, what we saw with this disease in those _ covid? now, what we saw with this disease in those patients _ covid? now, what we saw with this disease in those patients who - covid? now, what we saw with this disease in those patients who had l disease in those patients who had become seriously ill with it, there is a lot of information within the body, particularly within the lung, which is why people start coughing, and, later, when they need more oxygen. so, we thought we need to tackle the inflammation and rheumatoid arthritis is an inflammatory condition, an inflammation of other parts of the body. but it is the same chemical messengers that drive the inflammation so people started suggesting let's use these anti—inflammatory drugs and we obviously thought they needed to be tested in rigorous chemical trials before they became standard throughout the health service. but the results have been pretty phenomenal both in terms of reducing the length of hospital stays and most importantly death. yes. the length of hospital stays and most importantly death. yes, we were thrilled when — most importantly death. yes, we were thrilled when we _ most importantly death. yes, we were thrilled when we saw _ most importantly death. yes, we were thrilled when we saw the _ most importantly death. yes, we were thrilled when we saw the results, - most importantly death. yes, we were thrilled when we saw the results, to i thrilled when we saw the results, to have a treatment that can reduce mortality from the more severe cases so in the sickest patients the fact we could reduce deaths by nearly a quarter and speed up peoples recovery, so, recoverfrom being in intensive care, getting out of hospital quicker and particularly when resources had been so stretched, this was fantastic news, as much as we could have hoped for. and in particular drugs we are talking about our sorry map, i believe? ~ . , ., ., , talking about our sorry map, i believe? ~ . , ., ., believe? we detected surreal map and took similar believe? we detected surreal map and look similar map. _ believe? we detected surreal map and took similar map, difficult _ believe? we detected surreal map and took similar map, difficult names - believe? we detected surreal map and took similar map, difficult names to i took similar map, difficult names to pronounce because there is a whole class of drugs and potentially there are more we need to investigate because although it is great we have made the process, for those that are seriously ill, there are still many dying from the condition. lats seriously ill, there are still many dying from the condition.- dying from the condition. lots of other existing _ dying from the condition. lots of other existing drugs _ dying from the condition. lots of other existing drugs being - dying from the condition. lots of - other existing drugs being examined as we speak to see if they could be effective in treating coronavirus? one of the things we have absolutely learnt over the last year is that the impact of them who contract the virus especially when they become quite ill are